Association of Antibiotic Use with the Resistance Epidemiology of Pseudomonas aeruginosa in a Hospital Setting: A Four-Year Retrospective Time Series Analysis

Background: Even though, Pseudomonas aeruginosa is a common cause of hospital-acquired infections, treatment challenging because decreasing rates susceptibility to many broad-spectrum antibiotics. Methods: Consumption data eight broad spectrum antimicrobial agents and resistance P. were collected for 48 consecutive months. Autoregressive integrated moving average (ARIMA) transfer functions models used develop relationships between antibiotic use resistance. Results: Positive correlations uses ciprofloxacin (p < 0.001), meropenem cefepime = 0.005) identified. Transfer function showed the quantified effect each these antibiotics on Regarding levofloxacin, ceftazidime, piperacillin/tazobactam imipenem, no significant found. For ceftazidime this was probably due their low consumption, while imipenem reason can possibly be ascribed already high established in hospital. Conclusion: In hospital setting, agents’ consumption epidemiology differs significantly one them. study, role precedent meropenem, development